![]() Spontaneous pain was positively correlated to VZV IgM. 25(OH)D was inversely correlated to spontaneous/brush-evoked pain. In conditional logistic regressions, independent predictors for PHN were hypovitaminosis D (AOR3.12, 95% CI1.73–5.61), malignancy (AOR3.21, 95% CI 1.38–7.48) and Helicobacter pylori-related peptic ulcer disease (AOR3.47, 95% CI 1.71–7.03). Prevalence (73.9%) of hypovitaminosis D in 88 patients was high. Independent predictors of PHN were presented as adjusted odds ratios(AOR) and 95% confidence intervals (CI). Part II (a cross-sectional study): To determine associations between 25(OH)D, VZV IgG/M, pain and items in the DN4 questionnaire at the first pain clinic visit of patients. Patients aged ≥50 years were automatically selected by ICD-9 codes for shingle/PHN. Part I (a case-control study): To investigate the prevalence and risk of hypovitaminosis D in postherpetic neuralgia (PHN) patients compared to those in gender/index-month/age-auto matched controls who underwent health examinations. A two-part retrospective hospital-based study was conducted. Hypovitaminosis D (25-hydroxyvitamin D (25(OH)D) <75 nmol/L) is associated with neuropathic pain and varicella-zoster virus (VZV) immunity.
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